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KCNQ2/3/4/5 Polyclonal Antibody, 100μg, (ATB-T2458)

$199.00
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Background: This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]Product datasheet: Overview Product Description KCNQ2/3/4/5 Polyclonal Antibody, 100μg, (ATB-T2458) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human KCNQ2/3/4/5 around the non-phosphorylation site of T217/246/223/251. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: KCNQ3-Related Disorders Bellini G, et al. , 1993. PMID 24851285 Expression of voltage-dependent potassium channels in first trimester human placentae. Mistry HD, et al. Placenta, 2014 May. PMID 24646441 A conserved threonine in the S1-S2 loop of KV7.2 and K V7.3 channels regulates voltage-dependent activation. Füll Y, et al. Pflugers Arch, 2013 Jun. PMID 23271449 Benign familial neonatal convulsions caused by mutation in KCNQ3, exon 6: a European case. Fister P, et al. Eur J Paediatr Neurol, 2013 May. PMID 23146207 Regions of KCNQ K(+) channels controlling functional expression. Choveau FS, et al. Front Physiol, 2012. PMID 23087646 Free PMC Article

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KCNQ2/3/4/5 Polyclonal Antibody, 100μg, (ATB-T2458)
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