Laminin α-1 Polyclonal Antibody, 100µg, (ATB-T2523)

Background: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.Product datasheet: Overview Product Description Laminin α-1 Polyclonal Antibody, 100µg, (ATB-T2523) Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human Laminin α-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Molecular cloning of the cDNA encoding human laminin A chain. Haaparanta T., Uitto J., Ruoslahti E., Engvall E.Matrix 11:151-160(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-674; VAL-1340; THR-1876 AND GLU-2002. DNA sequence and analysis of human chromosome 18. Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.Nature 437:551-555(2005) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Primary structure of the human laminin A chain. Limited expression in human tissues. Nissinen M., Vuolteenaho R., Boot-Handford R., Kallunki P., Tryggvason K.Biochem. J. 276:369-379(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-2628, VARIANTS THR-674; THR-1876 AND GLU-2002. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. Olsen D., Nagayoshi T., Fazio M., Peltonen J., Jaakkola S., Sanborn D., Sasaki T., Kuivaniemi H., Chu M.-L., Deutzmann R., Timpl R., Uitto J.Lab. Invest. 60:772-782(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2397-3072. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2243. Tissue: Liver. Mutations in LAMA1 cause cerebellar dysplasia and cysts with and without retinal dystrophy. University of Washington Center for Mendelian Genomics, Care4Rare CanadaAldinger K.A., Mosca S.J., Tetreault M., Dempsey J.C., Ishak G.E., Hartley T., Phelps I.G., Lamont R.E., O'Day D.R., Basel D., Gripp K.W., Baker L., Stephan M.J., Bernier F.P., Boycott K.M., Majewski J., Parboosingh J.S., Innes A.M., Doherty D.Am. J. Hum. Genet. 95:227-234(2014) [PubMed] [Europe PMC] Cited for: INVOLVEMENT IN PTBHS. A secreted tyrosine kinase acts in the extracellular environment. Bordoli M.R., Yum J., Breitkopf S.B., Thon J.N., Italiano J.E. Jr., Xiao J., Worby C., Wong S.K., Lin G., Edenius M., Keller T.L., Asara J.M., Dixon J.E., Yeo C.Y., Whitman M.Cell 158:1033-1044(2014) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION.