Laminin-R Polyclonal Antibody, 100μg, (ATB-T2533)

Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Laminin-R Polyclonal Antibody, 100μg, (ATB-T2533) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human Laminin-R. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The 37kDa/67kDa laminin receptor acts as a receptor for Aβ42 internalization. Da Costa Dias B, et al. Sci Rep, 2014 Jul 3. PMID 24990253 Free PMC Article MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and MAPK pathway in gastric cancer. Sun L, et al. Cancer Sci, 2014 Jun. PMID 24703465 RPSA gene mutants associated with risk of colorectal cancer among the chinese population. Zhang SC, et al. Asian Pac J Cancer Prev, 2013. PMID 24460263 Laminin receptor 37/67LR regulates adhesion and proliferation of normal human intestinal epithelial cells. Khalfaoui T, et al. PLoS One, 2013. PMID 23991217 Free PMC Article MGr1-Ag promotes invasion and bone metastasis of small-cell lung cancer in vitro and in vivo. Zhang F, et al. Oncol Rep, 2013 Jun. PMID 23588894