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MAN1B1 Polyclonal Antibody, 100μg, (ATB-T2633)
Background: This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]Product datasheet: Overview Product Description MAN1B1 Polyclonal Antibody, 100μg, (ATB-T2633) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human MAN1B1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Diagnostic serum glycosylation profile in patients with intellectual disability as a result of MAN1B1 deficiency. Van Scherpenzeel M, et al. Brain, 2014 Apr. PMID 24566669 MAN1B1 deficiency: an unexpected CDG-II. Rymen D, et al. PLoS Genet, 2013. PMID 24348268 Free PMC Article ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC). Pan S, et al. PLoS One, 2013. PMID 23940818 Free PMC Article Mutations in the alpha 1,2-mannosidase gene, MAN1B1, cause autosomal-recessive intellectual disability. Rafiq MA, et al. Am J Hum Genet, 2011 Jul 15. PMID 21763484 Free PMC Article Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system. Pan S, et al. Mol Biol Cell, 2011 Aug 15. PMID 21697506 Free PMC Article
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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