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MAPKAPK-2 Polyclonal Antibody, 100μg, (ATB-T2640)

$199.00
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Background: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description MAPKAPK-2 Polyclonal Antibody, 100μg, (ATB-T2640) Image Species Reactivities Human,Mouse,Rat,Monkey Immunogen Synthesized peptide derived from human MAPKAPK-2 around the non-phosphorylation site of S272. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells. Köpper F, et al. Cell Cycle, 2014. PMID 24556918 The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection. Yang L, et al. Carcinogenesis, 2014 Jan. PMID 24056810 A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer. Liu B, et al. Am J Hum Genet, 2012 Aug 10. PMID 22883146 Free PMC Article Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series. Oubrie A, et al. Bioorg Med Chem Lett, 2012 Jan 1. PMID 22119462 MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Chang E, et al. Blood, 2011 Feb 24. PMID 21131586 Free PMC Article

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MAPKAPK-2 Polyclonal Antibody, 100μg, (ATB-T2640)
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