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MC4-R Polyclonal Antibody, 100μg, (ATB-T2675)

$199.00
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Background: The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]Product datasheet: Overview Product Description MC4-R Polyclonal Antibody, 100μg, (ATB-T2675) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human MC4-R. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Structural insight into the MC4R conformational changes via different agonist-mediated receptor signaling. Yang Y, et al. Biochemistry, 2014 Nov 18. PMID 25347793 Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children. Muller YL, et al. Hum Genet, 2014 Nov. PMID 25103139 Free PMC Article Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues. van der Klaauw AA, et al. J Clin Endocrinol Metab, 2014 Oct. PMID 25062455 Free PMC Article Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. Evans DS, et al. PLoS One, 2014. PMID 24820477 Free PMC Article Variation in the MC4R gene is associated with bone phenotypes in elderly Swedish women. Garg G, et al. PLoS One, 2014. PMID 24516669 Free PMC Article

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MC4-R Polyclonal Antibody, 100μg, (ATB-T2675)
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