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MCM3 Polyclonal Antibody, 100μg, (ATB-T15217)

$199.00
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Product Details

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]Product datasheet: Overview Product Description MCM3 Polyclonal Antibody, 100μg, (ATB-T15217) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human MCM3. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: MCM3 as a novel diagnostic marker in benign and malignant salivary gland tumors. Ashkavandi ZJ, et al. Asian Pac J Cancer Prev, 2013. PMID 23886132 MCM3 protein expression in follicular and classical variants of papillary thyroid carcinoma. Igci YZ, et al. Pathol Oncol Res, 2014 Jan. PMID 23821456 Human cytomegalovirus IE86 protein binds to cellular Mcm3 protein but does not inhibit its binding to the Epstein-Barr virus oriP in U373MG-p220.2 cells. Song YJ, et al. Acta Virol, 2010. PMID 20545442 Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. Söling A, et al. Clin Cancer Res, 2005 Jan 1. PMID 15671553 Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis. Ha SA, et al. Clin Cancer Res, 2004 Dec 15. PMID 15623617

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MCM3 Polyclonal Antibody, 100μg, (ATB-T15217)
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