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MCT8 Polyclonal Antibody, 100μg, (ATB-T2686)
Background: This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]Product datasheet: Overview Product Description MCT8 Polyclonal Antibody, 100μg, (ATB-T2686) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human MCT8. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: MCT8 expression in human fetal cerebral cortex is reduced in severe intrauterine growth restriction. Chan SY, et al. J Endocrinol, 2014 Feb. PMID 24204008 Free PMC Article Associations between single nucleotide polymorphisms in thyroid hormone transporter genes (MCT8, MCT10 and OATP1C1) and circulating thyroid hormones. Roef GL, et al. Clin Chim Acta, 2013 Oct 21. PMID 23978482 [MCT8-specific thyroid hormone cell transporter deficiency: a case report and review of the literature]. López-Marín L, et al. Rev Neurol, 2013 Jun 16. PMID 23744248 Importance of His192 in the human thyroid hormone transporter MCT8 for substrate recognition. Groeneweg S, et al. Endocrinology, 2013 Jul. PMID 23610131 Relevance of different cellular models in determining the effects of mutations on SLC16A2/MCT8 thyroid hormone transporter function and genotype-phenotype correlation. Capri Y, et al. Hum Mutat, 2013 Jul. PMID 23568789
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At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
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- Immunohistochemistry Tools
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