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ME2 Polyclonal Antibody, 100μg, (ATB-T2694)

$199.00
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Background: This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]Product datasheet: Overview Product Description ME2 Polyclonal Antibody, 100μg, (ATB-T2694) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human ME2. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2. Ren JG, et al. PLoS One, 2010 Sep 2. PMID 20824065 Free PMC Article Variation in the malic enzyme 2 gene: implications for the pharmacogenomics of psychotic disorders. Escamilla M. Pharmacogenomics, 2007 Jul. PMID 17638511 Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. Lenzen KP, et al. Epilepsia, 2005 Oct. PMID 16190936 Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme. Hung HC, et al. Biochemistry, 2005 Sep 27. PMID 16171388 Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. Greenberg DA, et al. Am J Hum Genet, 2005 Jan. PMID 15532013 Free PMC Article

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ME2 Polyclonal Antibody, 100μg, (ATB-T2694)
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