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MLC-2 Polyclonal Antibody, 100μg, (ATB-T2778)
Background: This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]Product datasheet: Overview Product Description MLC-2 Polyclonal Antibody, 100μg, (ATB-T2778) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human MLC-2 around the non-phosphorylation site of T17/S18. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. Grant JW, et al. Nucleic Acids Res, 1990 Oct 11. PMID 2216787 Free PMC Article AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. Höpker K, et al. EMBO J, 2012 Oct 17. PMID 22909821 Free PMC Article Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. Tan I, et al. FEBS Lett, 2011 May 6. PMID 21457715 Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. Iwasaki T, et al. Cell Struct Funct, 2001 Dec. PMID 11942626 Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells. Kobayashi K, et al. Brain Res, 2007 Sep 19. PMID 17719568
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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