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MLK3 Polyclonal Antibody, 100μg, (ATB-T2786)

$199.00
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Product Details

Background: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description MLK3 Polyclonal Antibody, 100μg, (ATB-T2786) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human MLK3 around the non-phosphorylation site of S674. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species. Lee HS, et al. Sci Signal, 2014 Jun 3. PMID 24894995 Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation. Velho S, et al. BMC Cancer, 2014 Mar 14. PMID 24628919 Free PMC Article Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis. Amako Y, et al. J Biol Chem, 2013 Aug 23. PMID 23857585 Free PMC Article Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. Zhan Y, et al. Exp Cell Res, 2012 Aug 15. PMID 22652451 Free PMC Article Mixed lineage kinase 3 modulates β-catenin signaling in cancer cells. Thylur RP, et al. J Biol Chem, 2011 Oct 28. PMID 21880738 Free PMC Article

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MLK3 Polyclonal Antibody, 100μg, (ATB-T2786)
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