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MLTK Polyclonal Antibody, 100µg, (ATB-T2790)
Background: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.Product datasheet: Overview Product Description MLTK Polyclonal Antibody, 100µg, (ATB-T2790) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the C-terminal region of human MLTK. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Liu T.-C., Huang C.-J., Chu Y.-C., Wei C.-C., Chou C.-C., Chou M.-Y., Chou C.-K., Yang J.-J.Biochem. Biophys. Res. Commun. 274:811-816(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, HOMODIMERIZATION, VARIANT LEU-531. Tissue: Placenta1 Publication
Manually curated information for which there is published experimental evidence.
More… Manual assertion based on experiment in i Ref.1 Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Liu T.-C., Huang C.-J., Chu Y.-C., Wei C.-C., Chou C.-C., Chou M.-Y., Chou C.-K., Yang J.-J.Biochem. Biophys. Res. Commun. 274:811-816(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, HOMODIMERIZATION, VARIANT LEU-531. . Identification and characterization of a novel MAP kinase kinase kinase, MLTK. Gotoh I., Adachi M., Nishida E.J. Biol. Chem. 276:4276-4286(2001) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, PHOSPHORYLATION, VARIANT LEU-531. Tissue: Fetal brain1 Publication
Manually curated information for which there is published experimental evidence.
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