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MLTK Polyclonal Antibody, 100μg, (ATB-T2789)

$199.00
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Background: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description MLTK Polyclonal Antibody, 100μg, (ATB-T2789) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human MLTK around the non-phosphorylation site of S165. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression. Jandhyala DM, et al. Cell Microbiol, 2008 Jul. PMID 18331592 ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells. Huang CY, et al. Biochem Biophys Res Commun, 2004 Nov 19. PMID 15485649 A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. Cho YY, et al. Cancer Res, 2004 Jun 1. PMID 15172994 Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. Bloem LJ, et al. J Mol Cell Cardiol, 2001 Sep. PMID 11549352 Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Liu TC, et al. Biochem Biophys Res Commun, 2000 Aug 11. PMID 10924358

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MLTK Polyclonal Antibody, 100μg, (ATB-T2789)
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