MNDA Polyclonal Antibody, 100µg, (ATB-T2803)

Background: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.Product datasheet: Overview Product Description MNDA Polyclonal Antibody, 100µg, (ATB-T2803) Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human MNDA. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. Briggs J.A., Burrus G.R., Stickney B.D., Briggs R.C.J. Cell. Biochem. 49:82-92(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas. Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins. Burrus G.R., Briggs J.A., Briggs R.C.J. Cell. Biochem. 48:190-202(1992) [PubMed] [Europe PMC] Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. Briggs R.C., Briggs J.A., Ozer J., Sealy L., Dworkin L.L., Kingsmore S.F., Seldin M.F., Kaur G.P., Athwal R.S., Dessypris E.N.Blood 83:2153-2162(1994) [PubMed] [Europe PMC] Cited for: INDUCTION. Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. Briggs R., Dworkin L., Briggs J., Dessypris E., Stein J., Stein G., Lian J.J. Cell. Biochem. 54:198-206(1994) [PubMed] [Europe PMC] Cited for: TISSUE SPECIFICITY OF ALPHA-INTERFERON INDUCTION. The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. Dawson M.J., Trapani J.A., Briggs R.C., Nicholl J.K., Sutherland G.R., Baker E.Immunogenetics 41:40-43(1995) [PubMed] [Europe PMC] Cited for: CHROMOSOMAL LOCATION, TISSUE SPECIFIC INDUCTION. Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. Xie J., Briggs J.A., Briggs R.C.3.0.CO;2-F">J. Cell. Biochem. 70:489-506(1998) [PubMed] [Europe PMC] Cited for: INTERACTION. Solution structure of the pyrin (PAAD-DAPIN) domain in human myeloid cell nuclear differentiation antigen. RIKEN structural genomics initiative (RSGI)Submitted (JUN-2006) to the PDB data bankCited for: STRUCTURE BY NMR OF 1-90.