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MxB Polyclonal Antibody, 100μg, (ATB-T2925)

$199.00
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Background: The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description MxB Polyclonal Antibody, 100μg, (ATB-T2925) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human MxB. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602. Tanaka S, et al. Sleep, 2008 May. PMID 18517045 Free PMC Article Identification of differentially expressed genes in blood cells of narcolepsy patients. Tanaka S, et al. Sleep, 2007 Aug. PMID 17702266 Free PMC Article Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB. King MC, et al. Proc Natl Acad Sci U S A, 2004 Jun 15. PMID 15184662 Free PMC Article Nuclear cotransport mechanism of cytoplasmic human MxB protein. Melén K, et al. J Biol Chem, 1997 Dec 19. PMID 9405443 Intracellular staining of Mx proteins in cells from peripheral blood, bone marrow and skin. al-Masri AN, et al. Mol Pathol, 1997 Feb. PMID 9208807 Free PMC Article

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MxB Polyclonal Antibody, 100μg, (ATB-T2925)
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