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MyoD Polyclonal Antibody, 100μg, (ATB-T2943)

$199.00
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Product Details

Background: This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description MyoD Polyclonal Antibody, 100μg, (ATB-T2943) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human MyoD around the non-phosphorylation site of S200. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: A MYOD1 mutation cooperates with PI3K pathway activation in ERMS. . Cancer Discov, 2014 Jul. PMID 25002625 Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis. Agaram NP, et al. Genes Chromosomes Cancer, 2014 Sep. PMID 24824843 Free PMC Article A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. Kohsaka S, et al. Nat Genet, 2014 Jun. PMID 24793135 Free PMC Article Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. Szuhai K, et al. J Pathol, 2014 Feb. PMID 24272621 Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors. MacQuarrie KL, et al. Mol Cell Biol, 2013 Feb. PMID 23230269 Free PMC Article

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MyoD Polyclonal Antibody, 100μg, (ATB-T2943)
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