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Myomesin-1 Polyclonal Antibody, 100μg, (ATB-T2946)
Background: The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Myomesin-1 Polyclonal Antibody, 100μg, (ATB-T2946) Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human Myomesin-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. Pinotsis N, et al. PLoS Biol, 2012 Feb. PMID 22347812 Free PMC Article Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1. Koebis M, et al. Genes Cells, 2011 Sep. PMID 21794030 A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties. Siegert R, et al. Biochem Biophys Res Commun, 2011 Feb 18. PMID 21256114 EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy. Schoenauer R, et al. Basic Res Cardiol, 2011 Mar. PMID 21069531 Free PMC Article Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. Pinotsis N, et al. EMBO J, 2008 Jan 9. PMID 18059477 Free PMC Article
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