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Myosin IXb Polyclonal Antibody, 100μg, (ATB-T2949)

$199.00
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Background: This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]Product datasheet: Overview Product Description Myosin IXb Polyclonal Antibody, 100μg, (ATB-T2949) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human Myosin IXb. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis. Nijmeijer RM, et al. PLoS One, 2013. PMID 24386489 Free PMC Article Frequency of MYO9B polymorphisms in celiac patients and controls. Loeff T, et al. Rev Esp Enferm Dig, 2012 Dec. PMID 23368647 Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma. Menke V, et al. Scand J Gastroenterol, 2012 Dec. PMID 22954106 A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation. Chandhoke SK, et al. Mol Biol Cell, 2012 Jul. PMID 22573889 Free PMC Article Association analysis of myosin IXB and type 1 diabetes. Persengiev S, et al. Hum Immunol, 2010 Jun. PMID 20303373

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Myosin IXb Polyclonal Antibody, 100μg, (ATB-T2949)
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