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NCoA-5 Polyclonal Antibody, 100μg, (ATB-T2997)

$199.00
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Product Details

Background: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description NCoA-5 Polyclonal Antibody, 100μg, (ATB-T2997) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human NCoA-5. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study. Zervou MI, et al. Hum Immunol, 2011 Sep. PMID 21645569 NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Gao S, et al. Cancer Cell, 2013 Dec 9. PMID 24332041 Free PMC Article TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. Jiang C, et al. J Biol Chem, 2004 Jun 25. PMID 15073177 Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Lewis JP, et al. Genomics, 2010 Oct. PMID 20650312 Free PMC Article CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. Sauvé F, et al. Mol Cell Biol, 2001 Jan. PMID 11113208 Free PMC Article

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NCoA-5 Polyclonal Antibody, 100μg, (ATB-T2997)
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