NFATc3 Polyclonal Antibody, 100µg, (ATB-T3083)

Background: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.Product datasheet: Overview Product Description NFATc3 Polyclonal Antibody, 100µg, (ATB-T3083) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human NFATc3 around the non-phosphorylation site of S165. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Hoey T., Sun Y.-L., Williamson K., Xu X.Immunity 2:461-472(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5 AND 6). Tissue: Skeletal muscle and T-cell. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Masuda E.S., Naito Y., Tokumitsu H., Campbell D., Saito F., Hannum C., Arai K., Arai N.Mol. Cell. Biol. 15:2697-2706(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: T-cell. Carboxy-terminal 15 amino acids sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells. Imamura R., Masuda E.S., Naito Y., Imai S., Fujino T., Takano T., Arai K., Arai N.J. Immunol. 161:3455-3463(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Fibroblast and T-cell. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D.Genomics 60:295-308(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 4). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney. Bienvenut W.V., Waridel P., Quadroni M.Submitted (MAR-2009) to UniProtKBCited for: PROTEIN SEQUENCE OF 2-15; 468-488; 505-519 AND 579-594, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY. Tissue: Embryonic kidney. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Zhu J., Shibasaki F., Price R., Guillemot J.-C., Yano T., Doetsch V., Wagner G., Ferrara P., McKeon F.Cell 93:851-861(1998) [PubMed] [Europe PMC] Cited for: MUTAGENESIS. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Crabtree G.R.Cell 96:611-614(1999) [PubMed] [Europe PMC] Cited for: REVIEW. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. Li G.D., Zhang X., Li R., Wang Y.D., Wang Y.L., Han K.J., Qian X.P., Yang C.G., Liu P., Wei Q., Chen W.F., Zhang J., Zhang Y.J. Biol. Chem. 283:32660-32668(2008) [PubMed] [Europe PMC] Cited for: FUNCTION, SUBCELLULAR LOCATION.