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NHE-7 Polyclonal Antibody, 100μg, (ATB-T3118)

$199.00
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Background: This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]Product datasheet: Overview Product Description NHE-7 Polyclonal Antibody, 100μg, (ATB-T3118) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human NHE-7. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The intracellular Na(+)/H(+) exchanger NHE7 effects a Na(+)-coupled, but not K(+)-coupled proton-loading mechanism in endocytosis. Milosavljevic N, et al. Cell Rep, 2014 May 8. PMID 24767989 Organellar (Na+, K+)/H+ exchanger NHE7 regulates cell adhesion, invasion and anchorage-independent growth of breast cancer MDA-MB-231 cells. Onishi I, et al. Oncol Rep, 2012 Feb. PMID 22076128 A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes. Fukura N, et al. J Membr Biol, 2010 Apr. PMID 20364249 Identification and biochemical characterization of the SLC9A7 interactome. Kagami T, et al. Mol Membr Biol, 2008 Aug. PMID 18654930 Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. Numata M, et al. J Biol Chem, 2001 May 18. PMID 11279194

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NHE-7 Polyclonal Antibody, 100μg, (ATB-T3118)
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