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Net Polyclonal Antibody, 100μg, (ATB-T3040)

$199.00
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Background: This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]Product datasheet: Overview Product Description Net Polyclonal Antibody, 100μg, (ATB-T3040) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human Net around the non-phosphorylation site of S357. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP. Heo SH, et al. Int J Biol Sci, 2014. PMID 24719561 Free PMC Article Growth inhibitory effect of the ternary complex factor Net on human pancreatic carcinoma cell lines. Li B, et al. Tohoku J Exp Med, 2008 Oct. PMID 18832796 The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. Ducret C, et al. Mol Cell Biol, 1999 Oct. PMID 10490644 Free PMC Article Involvement of net and Hif1alpha in distinct yet intricately linked hypoxia-induced signaling pathways. Serchov T, et al. J Biol Chem, 2010 Jul 9. PMID 20427288 Free PMC Article Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net. Wasylyk C, et al. Oncogene, 2005 Jan 27. PMID 15580297

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Net Polyclonal Antibody, 100μg, (ATB-T3040)
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