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Neuregulin-1 Polyclonal Antibody, 100μg, (ATB-T15319)

$199.00
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Product Details

Background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014]Product datasheet: Overview Product Description Neuregulin-1 Polyclonal Antibody, 100μg, (ATB-T15319) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human Neuregulin-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Paterson C, et al. Am J Psychiatry, 2014 Sep. PMID 24935406 Association of the 3' region of the neuregulin 1 gene with bipolar I disorder in the Chinese Han population. Cao L, et al. J Affect Disord, 2014 Jun. PMID 24767010 Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches. Marballi KK, et al. J Neural Transm, 2014 May. PMID 24380930 Activation of microglial neuregulin1 signaling in the corticospinal tracts of ALS patients with upper motor neuron signs. Song F, et al. Amyotroph Lateral Scler Frontotemporal Degener, 2014 Mar. PMID 24229388 Changes of neuregulin-1 (NRG-1) expression in a rat model of overactive bladder induced by partial urethral obstruction: is NRG-1 a new biomarker of overactive bladder? Jang H, et al. BMC Urol, 2013 Oct 23. PMID 24152577 Free PMC Article

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Neuregulin-1 Polyclonal Antibody, 100μg, (ATB-T15319)
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