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Neuregulin-2 Polyclonal Antibody, 100μg, (ATB-T15215)

$199.00
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Background: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]Product datasheet: Overview Product Description Neuregulin-2 Polyclonal Antibody, 100μg, (ATB-T15215) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human Neuregulin-2. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing. Ponomareva ON, et al. Neuroscience, 2005. PMID 15961242 The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis. Nakano N, et al. J Biol Chem, 2004 Mar 19. PMID 14722120 The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. Ring HZ, et al. Hum Genet, 1999 Apr. PMID 10369162 Inter-conversion of neuregulin2 full and partial agonists for ErbB4. Wilson KJ, et al. Biochem Biophys Res Commun, 2007 Dec 14. PMID 17945187 Free PMC Article Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene. Fan BJ, et al. Mol Vis, 2007 May 23. PMID 17563728 Free PMC Article

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Neuregulin-2 Polyclonal Antibody, 100μg, (ATB-T15215)
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