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Op18 Polyclonal Antibody, 100μg, (ATB-T3463)

$199.00
In stock
Product Details

Background: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]Product datasheet: Overview Product Description Op18 Polyclonal Antibody, 100μg, (ATB-T3463) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Op18 around the non-phosphorylation site of S62. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Stathmin is a marker of progression and poor prognosis in esophageal carcinoma. Wang F, et al. Asian Pac J Cancer Prev, 2014. PMID 24870766 STMN-1 is a potential marker of lymph node metastasis in distal esophageal adenocarcinomas and silencing its expression can reverse malignant phenotype of tumor cells. Akhtar J, et al. BMC Cancer, 2014 Jan 16. PMID 24433541 Free PMC Article Stathmin overexpression identifies high risk for lymphatic metastatic recurrence in pN0 esophageal squamous cell carcinoma patients. Akhtar J, et al. J Gastroenterol Hepatol, 2014 May. PMID 24372619 Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells. Machado-Neto JA, et al. Leuk Res, 2014 Feb. PMID 24355524 A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells. Wu Y, et al. Cell Oncol (Dordr), 2014 Feb. PMID 24306928

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Op18 Polyclonal Antibody, 100μg, (ATB-T3463)
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