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Orexin R-1 Polyclonal Antibody, 100μg, (ATB-T3472)

$199.00
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Product Details

Background: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]Product datasheet: Overview Product Description Orexin R-1 Polyclonal Antibody, 100μg, (ATB-T3472) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human Orexin R-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis. Alexandre D, et al. Eur J Cancer, 2014 Aug. PMID 24910418 OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release. Turunen PM, et al. Mol Pharmacol, 2012 Aug. PMID 22550093 Evidence for an association between migraine and the hypocretin receptor 1 gene. Rainero I, et al. J Headache Pain, 2011 Apr. PMID 21344296 Free PMC Article Arachidonic acid release mediated by OX1 orexin receptors. Turunen PM, et al. Br J Pharmacol, 2010 Jan. PMID 20002100 Free PMC Article Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis. El Firar A, et al. FASEB J, 2009 Dec. PMID 19661287

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Orexin R-1 Polyclonal Antibody, 100μg, (ATB-T3472)
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