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PC-PLD1 Polyclonal Antibody, 100μg, (ATB-T3618)

$199.00
In stock
Product Details

Background: This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]Product datasheet: Overview Product Description PC-PLD1 Polyclonal Antibody, 100μg, (ATB-T3618) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human PC-PLD1 around the non-phosphorylation site of S561. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus. Jang YH, et al. Exp Mol Med, 2012 Oct 31. PMID 22824913 Free PMC Article Diacylglycerol stimulates acrosomal exocytosis by feeding into a PKC- and PLD1-dependent positive loop that continuously supplies phosphatidylinositol 4,5-bisphosphate. Lopez CI, et al. Biochim Biophys Acta, 2012 Sep. PMID 22609963 IL-15 promotes osteoclastogenesis via the PLD pathway in rheumatoid arthritis. Park MK, et al. Immunol Lett, 2011 Sep 30. PMID 21620893 Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis. Kang DW, et al. Cancer Res, 2010 May 15. PMID 20442281 Roles of phospholipase D in phorbol myristate acetate-stimulated neutrophil respiratory burst. Hu T, et al. J Cell Mol Med, 2011 Mar. PMID 20158570

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PC-PLD1 Polyclonal Antibody, 100μg, (ATB-T3618)
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