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PEA-15 Polyclonal Antibody, 100μg, (ATB-T3654)

$199.00
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Product Details

Background: This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]Product datasheet: Overview Product Description PEA-15 Polyclonal Antibody, 100μg, (ATB-T3654) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human PEA-15. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation. Nagarajan A, et al. Mol Cell Biol, 2014 Jun. PMID 24710276 Free PMC Article Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells. Quintavalle C, et al. J Cell Physiol, 2014 Oct. PMID 24477641 Free PMC Article Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15). Thomason LA, et al. FEBS Lett, 2013 Aug 2. PMID 23792157 Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy. Farina B, et al. Biochim Biophys Acta, 2013 Aug. PMID 23608947 The PEA-15/PED protein regulates cellular survival and invasiveness in colorectal carcinomas. Funke V, et al. Cancer Lett, 2013 Jul 28. PMID 23481023

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PEA-15 Polyclonal Antibody, 100μg, (ATB-T3654)
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