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PEG3 Polyclonal Antibody, 100μg, (ATB-T3659)
Background: In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]Product datasheet: Overview Product Description PEG3 Polyclonal Antibody, 100μg, (ATB-T3659) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human PEG3. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Structure of the SCAN domain of human paternally expressed gene 3 protein. Rimsa V, et al. PLoS One, 2013. PMID 23936039 Free PMC Article Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer. Nye MD, et al. PLoS One, 2013. PMID 23418553 Free PMC Article The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. Jiang X, et al. J Biol Chem, 2010 Mar 12. PMID 20064927 Free PMC Article Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma. Otsuka S, et al. Proc Jpn Acad Ser B Phys Biol Sci, 2009. PMID 19367087 Free PMC Article Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. Dowdy SC, et al. Gynecol Oncol, 2005 Oct. PMID 16023706
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