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PEPCK-C Polyclonal Antibody, 100μg, (ATB-T15236)

$199.00
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Product Details

Background: This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description PEPCK-C Polyclonal Antibody, 100μg, (ATB-T15236) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human PEPCK-C. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects. Perez-Martinez P, et al. Clin Nutr, 2013 Aug. PMID 23092637 A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. Xia Z, et al. PLoS One, 2010 Nov 30. PMID 21152065 Free PMC Article Lack of association between PCK1 polymorphisms and obesity, physical activity, and fitness in European Youth Heart Study (EYHS). Vimaleswaran KS, et al. Obesity (Silver Spring), 2010 Oct. PMID 20134411 The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population. Rees SD, et al. BMC Med Genet, 2009 Sep 2. PMID 19725958 Free PMC Article Identification of conserved regulatory elements in mammalian promoter regions: a case study using the PCK1 promoter. Liu GE, et al. Genomics Proteomics Bioinformatics, 2008 Dec. PMID 19329064

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PEPCK-C Polyclonal Antibody, 100μg, (ATB-T15236)
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