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PFK-2 liv Polyclonal Antibody, 100μg, (ATB-T3683)

$199.00
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Background: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]Product datasheet: Overview Product Description PFK-2 liv Polyclonal Antibody, 100μg, (ATB-T3683) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human PFK-2 liv. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21. Batra RS, et al. Genomics, 1997 Mar 1. PMID 9119406 Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase. Algaier J, et al. Biochem Biophys Res Commun, 1988 May 31. PMID 2837207 Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression. Marker AJ, et al. J Biol Chem, 1989 Apr 25. PMID 2540168 Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Lange AJ, et al. Nucleic Acids Res, 1990 Jun 25. PMID 2163524 Free PMC Article Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Lee YH, et al. J Biol Chem, 2003 Jan 3. PMID 12379646

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PFK-2 liv Polyclonal Antibody, 100μg, (ATB-T3683)
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