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PP2A-B56-α Polyclonal Antibody, 100μg, (ATB-T3828)

$199.00
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Product Details

Background: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]Product datasheet: Overview Product Description PP2A-B56-α Polyclonal Antibody, 100μg, (ATB-T3828) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human PP2A-B56-α. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Foley EA, et al. Nat Cell Biol, 2011 Aug 28. PMID 21874008 Free PMC Article Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage. Freeman AK, et al. Cell Cycle, 2010 Feb 15. PMID 20160490 Free PMC Article Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41. Kirchhefer U, et al. J Biol Chem, 2014 Jan 3. PMID 24225947 Free PMC Article A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1. Pitman MR, et al. Int J Biochem Cell Biol, 2011 Mar. PMID 21075214 Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit. Flegg CP, et al. J Biol Chem, 2010 Jun 11. PMID 20378546 Free PMC Article

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PP2A-B56-α Polyclonal Antibody, 100μg, (ATB-T3828)
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