PP2A-Cα Polyclonal Antibody, 100µg, (ATB-T3830)

Background: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.Product datasheet: Overview Product Description PP2A-Cα Polyclonal Antibody, 100µg, (ATB-T3830) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human PP2A-Cα around the non-phosphorylation site of Y307. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit. Stone S.R., Mayer R., Wernet W., Maurer F., Hofsteenge J., Hemmings B.A.Nucleic Acids Res. 16:11365-11365(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fibroblast. Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. Arino J., Woon C.W., Brautigan D.L., Miller T.B. Jr., Johnson G.L.Proc. Natl. Acad. Sci. U.S.A. 85:4252-4256(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. Khew-Goodall Y., Mayer R.E., Maurer F., Stone S.R., Hemmings B.A.Biochemistry 30:89-97(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung, Placenta and Uterus. Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. Scheidtmann K.H., Mumby M.C., Rundell K., Walter G.Mol. Cell. Biol. 11:1996-2003(1991) [PubMed] [Europe PMC] Cited for: DEPHOSPHORYLATION OF SV40 LARGE-T ANTIGEN AND P53 PROTEIN. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. Favre B., Zolnierowicz S., Turowski P., Hemmings B.A.J. Biol. Chem. 269:16311-16317(1994) [PubMed] [Europe PMC] Cited for: METHYLATION AT LEU-309. Alpha 4 associates with protein phosphatases 2A, 4, and 6. Chen J., Peterson R.T., Schreiber S.L.Biochem. Biophys. Res. Commun. 247:827-832(1998) [PubMed] [Europe PMC] Cited for: INTERACTION WITH IGBP1. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. Bryant J.C., Westphal R.S., Wadzinski B.E.Biochem. J. 339:241-246(1999) [PubMed] [Europe PMC] Cited for: MUTAGENESIS OF LEU-309. Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. Virshup D.M., Kauffman M.G., Kelly T.J.EMBO J. 8:3891-3898(1989) [PubMed] [Europe PMC] Cited for: PARTIAL PROTEIN SEQUENCE, ACTIVATION OF SV40 REPLICATION. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. Hsu W., Zeng L., Costantini F.J. Biol. Chem. 274:3439-3445(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH AXIN1, FUNCTION.