Phospho-BAM32 (Y139) Polyclonal Antibody, 100µg, (ATB-P0549)

Background: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.Product datasheet: Overview Product Description Phospho-BAM32 (Y139) Polyclonal Antibody, 100µg, (ATB-P0549) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human BAM32 around the phosphorylation site of Y139. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation. Ortner D, et al. J Immunol, 2011 Oct 15. PMID 21930970 The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. Niiro H, et al. J Immunol, 2004 Nov 1. PMID 15494510 The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival. Niiro H, et al. J Exp Med, 2002 Jan 7. PMID 11781373 Free PMC Article Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Ferguson KM, et al. Mol Cell, 2000 Aug. PMID 10983984 The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. Allam A, et al. J Biol Chem, 2004 Sep 17. PMID 15247305 DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Dowler S., Currie R.A., Downes C.P., Alessi D.R.Biochem. J. 342:7-12(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH PTDINS(3,4,5)P3 AND PTDINS(3,4)P2, MUTAGENESIS OF LYS-173 AND TRP-250. A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. Marshall A.J., Niiro H., Lerner C.G., Yun T.J., Thomas S., Disteche C.M., Clark E.A.J. Exp. Med. 191:1319-1332(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, INTERACTION WITH PLCG2, MUTAGENESIS OF ARG-61; ARG-184 AND LYS-197. Molecular cloning of a protein-tyrosine phosphatase D. Zhang W., Wan T., Cao X.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z.Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Umbilical cord blood. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Urinary bladder wart.