Phospho-Bcl-2 (S70) Polyclonal Antibody, 100µg, (ATB-P0492)

Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).Product datasheet: Overview Product Description Phospho-Bcl-2 (S70) Polyclonal Antibody, 100µg, (ATB-P0492) Image Species Reactivities Mouse,Rat Immunogen Synthesized peptide derived from human Bcl-2 around the phosphorylation site of S70. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: [Inhibition of Bcl-2 stimulates neuronal stem proliferation in organotypic cultures of mice hippocampus]. Beliaeva IaS, et al. Ross Fiziol Zh Im I M Sechenova, 2013 Aug. PMID 25470948 Initiation of premature senescence by Bcl-2 in hypoxic condition. Wang W, et al. Int J Clin Exp Pathol, 2014. PMID 24966955 Free PMC Article Loss of Bcl-2 expression correlates with increasing sensitivity to apoptosis in differentiating ES cells. Nagahara Y, et al. Cell Biol Int, 2014 Mar. PMID 24293136 Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes. Schöneich C, et al. Apoptosis, 2014 Jan. PMID 24129924 Free PMC Article Heligmosomoides polygyrus antigens inhibit the intrinsic pathway of apoptosis by overexpression of survivin and Bcl-2 protein in CD4 T cells. Donskow-Łysoniewska K, et al. Prion, 2013 Jul-Aug. PMID 23787700 Free PMC Article Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Negrini M., Silini E., Kozak C., Tsujimoto Y., Croce C.M.Cell 49:455-463(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA AND BETA). Strain: BALB/c. Tissue: Liver. Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo. Eguchi Y., Ewert D.L., Tsujimoto Y.Nucleic Acids Res. 20:4187-4192(1992) [PubMed] [Europe PMC] Cited for: SEQUENCE REVISION TO 221-222. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.