Phospho-Bcr (Y177) Polyclonal Antibody, 100 µg, (ATB-P0036)

Background: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.Product datasheet: Overview Product Description Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human Bcr around the phosphorylation site of Y177. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: bcr genes and transcripts. Lifshitz B., Fainstein E., Marcelle C., Shtivelman E., Amson R., Gale R.P., Canaani E.Oncogene 2:113-117(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT SER-796. Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Chissoe S.L., Bodenteich A., Wang Y.-F., Wang Y.-P., Burian D., Clifton S.W., Crabtree J., Freeman A., Iyer K., Jian L., Ma Y., McLaury H.-J., Pan H.-Q., Sarhan O.H., Toth S., Wang Z., Zhang G., Heisterkamp N., Groffen J., Roe B.A.Genomics 27:67-82(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method. Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-796. Tissue: Brain. cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia. Hariharan I.K., Adams J.M.EMBO J. 6:115-119(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-872, VARIANT SER-796. Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome. Mes-Masson A.-M., McLaughlin J., Daley G.Q., Paskind M., Witte O.N.Proc. Natl. Acad. Sci. U.S.A. 83:9768-9772(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-693. ErratumMes-Masson A.M., McLaughlin J., Daley G.Q., Paskind M., Witte O.N.Proc. Natl. Acad. Sci. U.S.A. 84:2507-2507(1987)Cited for: SEQUENCE REVISION. Structural organization of the bcr gene and its role in the Ph' translocation. Heisterkamp N., Stam K., Groffen J., de Klein A., Grosveld G.Nature 315:758-761(1985) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 683-1271 (ISOFORM 1). Unique organization of the human BCR gene promoter. Zhu Q.S., Heisterkamp N., Groffen J.Nucleic Acids Res. 18:7119-7125(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46 AND 275-426. A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia. Fainstein E., Marcelle C., Rosner A., Canaani E., Gale R.P., Dreazen O., Smith S.D., Croce C.M.Nature 330:386-388(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-426. Alternative 5' end of the bcr-abl transcript in chronic myelogenous leukemia. Romero P., Beran M., Shtalrid M., Andersson B., Talpaz M., Blick M.Oncogene 4:93-98(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 362-438, ALTERNATIVE SPLICING.