Phospho-C/EBP ε (T74) Polyclonal Antibody, 100µg, (ATB-P0911)

Background: The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.Product datasheet: Overview Product Description Phospho-C/EBP ε (T74) Polyclonal Antibody, 100µg, (ATB-P0911) Image Species Reactivities Human Immunogen Synthesized peptide derived from human C/EBP ε around the phosphorylation site of T74. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Identification of functional nucleotide and haplotype variants in the promoter of the CEBPE gene. Ryoo H, et al. J Hum Genet, 2013 Sep. PMID 23719191 Double CEBPE-IGH rearrangement due to chromosome duplication and cryptic insertion in an adult with B-cell acute lymphoblastic leukemia. Pierini V, et al. Cancer Genet, 2011 Oct. PMID 22137487 Human C/EBP-epsilon activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation. Bedi R, et al. Blood, 2009 Jan 8. PMID 18832658 Free PMC Article Identification of a responsible promoter region and a key transcription factor, CCAAT/enhancer-binding protein epsilon, for up-regulation of PHGPx in HL60 cells stimulated with TNF alpha. Hattori H, et al. Biochem J, 2007 Dec 1. PMID 17688422 Free PMC Article Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon). Gombart AF, et al. Curr Opin Hematol, 2002 Jan. PMID 11753076 A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. Antonson P., Stellan B., Yamanaka R., Xanthopoulos K.G.Genomics 35:30-38(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. Chumakov A.M., Grillier I., Chumakova E., Chih D., Slater J., Koeffler H.P.Mol. Cell. Biol. 17:1375-1386(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.