Phospho-CD28 (Y218) Polyclonal Antibody, 100µg, (ATB-P0348)

Background: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.Product datasheet: Overview Product Description Phospho-CD28 (Y218) Polyclonal Antibody, 100µg, (ATB-P0348) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human CD28 around the phosphorylation site of Y218. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Quantitative assessment of the associations between CD28 T > C polymorphism (rs3116496) and cancer risk. Cong J, et al. Tumour Biol, 2014 Sep. PMID 24927673 CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma. Murray ME, et al. Blood, 2014 Jun 12. PMID 24782505 Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis. Liaskou E, et al. Gastroenterology, 2014 Jul. PMID 24726754 Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08. Tabares P, et al. Eur J Immunol, 2014 Apr. PMID 24374661 Association between IVS3 +17T/C CD28 gene polymorphism and the acute kidney allograft rejection. Pawlik A, et al. Transpl Immunol, 2014 Mar. PMID 24368148 Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Aruffo A., Seed B.Proc. Natl. Acad. Sci. U.S.A. 84:8573-8577(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity. Lee K.P., Taylor C., Petryniak B., Turka L.A., June C.H., Thompson C.B.J. Immunol. 145:344-352(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING. A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes. Deshpande M., Venuprasad K., Parab P.B., Saha B., Mitra D.Hum. Immunol. 63:20-23(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28. Hanawa H., Ma Y., Mikolajczak S.A., Charles M.L., Yoshida T., Yoshida R., Strathdee C.A., Litchfield D.W., Ochi A.Blood 99:2138-2145(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 6), CHARACTERIZATION (ISOFORM 3). Tissue: Peripheral blood T-cell. New human CD28 isoforms generated by a novel splicing event in the 5'UTR. Gan S.U., Hare J., Krivoshchapov L., Hui K.M., Galea-Lauri J., Farzaneh F., Darling D.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).