Phospho-Casein Kinase IIβ (S209) Polyclonal Antibody, 100µg, (ATB-P0732)

Background: This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.Product datasheet: Overview Product Description Phospho-Casein Kinase IIβ (S209) Polyclonal Antibody, 100µg, (ATB-P0732) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Casein Kinase IIβ around the phosphorylation site of S209. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: [Effect of casein kinase 2β in esophageal carcinoma and its clinical significance]. Chen B, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2012 Oct. PMID 23076192 Regulation of epithelial to mesenchymal transition: CK2β on stage. Deshiere A, et al. Mol Cell Biochem, 2011 Oct. PMID 21755461 [Correlation of casein kinase 2β overexpression to the metastatic ability of colorectal cancer cells in vitro]. Zou JJ, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2011 Apr. PMID 21515457 Interaction of human cytomegalovirus pUL84 with casein kinase 2 is required for oriLyt-dependent DNA replication. Gao Y, et al. J Virol, 2009 Mar. PMID 19091862 Free PMC Article CK2beta is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation. Pallares J, et al. Am J Pathol, 2009 Jan. PMID 19056846 Free PMC Article Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta. Jakobi R., Voss H., Pyerin W.Eur. J. Biochem. 183:227-233(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. Teitz T., Eli D., Penner M., Bakhanashvili M., Naiman T., Timme T.L., Wood C.M., Moses R.E., Canaani D.Mutat. Res. 236:85-97(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II. Heller-Harrison R.A., Meisner H., Czech M.P.Biochemistry 28:9053-9058(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Structure of the gene encoding human casein kinase II subunit beta. Voss A., Wirkner U., Jacobi R., Hewitt N., Schwager C., Zimmermann J., Ansorge W., Pyerin W.J. Biol. Chem. 266:13706-13711(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. Singh L.S., Kalafatis M.Biochemistry 41:8935-8940(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].