Phospho-Cytokeratin 18 (S33) Polyclonal Antibody, 100 µg, (ATB-P0859)

Background: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.Product datasheet: Overview Product Description Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Cytokeratin 18 around the phosphorylation site of S33. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation. Oshima R.G., Millan J.L., Cecena G.Differentiation 33:61-68(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Placenta. Identification of a cell proliferation-inducing gene. Kim J.W.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Cloning of human full-length CDSs in BD Creator(TM) system donor vector. Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix, Colon, Pancreas, Placenta and Uterus. Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells. Kulesh D.A., Oshima R.G.Mol. Cell. Biol. 8:1540-1550(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-167. Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ. Leube R.E., Bosch F.X., Romano V., Zimbelmann R., Hofler H., Franke W.W.Differentiation 33:69-85(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-430, TISSUE SPECIFICITY. Tissue: Vulva. Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone. Romano V., Hatzfeld M., Magin T.M., Zimbelmann R., Franke W.W., Maier G., Ponstingl H.Differentiation 30:244-253(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 199-430, TISSUE SPECIFICITY. Tissue: Liver. A two-dimensional gel database of human colon carcinoma proteins. Ji H., Reid G.E., Moritz R.L., Eddes J.S., Burgess A.W., Simpson R.J.Electrophoresis 18:605-613(1997) [PubMed] [Europe PMC] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Colon carcinoma. Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. Chou C.F., Smith A.J., Omary M.B.J. Biol. Chem. 267:3901-3906(1992) [PubMed] [Europe PMC] Cited for: GLYCOSYLATION.