Phospho-DAPK2 (S318) Polyclonal Antibody, 100µg, (ATB-P1142)

Background: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.Product datasheet: Overview Product Description Phospho-DAPK2 (S318) Polyclonal Antibody, 100µg, (ATB-P1142) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human DAPK2 around the phosphorylation site of S318. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. Li H, et al. J Biol Chem, 2009 Jan 23. PMID 18957423 The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. Rizzi M, et al. J Leukoc Biol, 2007 Jun. PMID 17347302 DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. Inbal B, et al. J Cell Biol, 2002 Apr 29. PMID 11980920 Free PMC Article High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients. Wong TS, et al. Clin Cancer Res, 2002 Feb. PMID 11839660 Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. Shani G, et al. EMBO J, 2001 Mar 1. PMID 11230133 Free PMC Article Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Kawai T., Nomura F., Hoshino K., Copeland N.G., Gilbert D.J., Jenkins N.A., Akira S.Oncogene 18:3471-3480(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-52. Tissue: Skeletal muscle1 Publication

Manually curated information for which there is published experimental evidence.

More… Manual assertion based on experiment in ⁱ Ref.1 Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Kawai T., Nomura F., Hoshino K., Copeland N.G., Gilbert D.J., Jenkins N.A., Akira S.Oncogene 18:3471-3480(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-52.