Phospho-GATA-3 (S308) Polyclonal Antibody, 100µg, (ATB-P1179)

Background: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.Product datasheet: Overview Product Description Phospho-GATA-3 (S308) Polyclonal Antibody, 100µg, (ATB-P1179) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human GATA-3 around the phosphorylation site of S308. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: GATA-3 expression in trophoblastic tissues: an immunohistochemical study of 445 cases, including diagnostic utility. Banet N, et al. Am J Surg Pathol, 2015 Jan. PMID 25188865 Diagnostic utility and sensitivities of GATA3 antibodies in triple-negative breast cancer. Krings G, et al. Hum Pathol, 2014 Nov. PMID 25150746 Semiquantitative GATA-3 immunoreactivity in breast, bladder, gynecologic tract, and other cytokeratin 7-positive carcinomas. Clark BZ, et al. Am J Clin Pathol, 2014 Jul. PMID 24926087 GATA3 expression in small cell carcinoma of bladder and prostate and its potential role in determining primary tumor origin. Bezerra SM, et al. Hum Pathol, 2014 Aug. PMID 24925221 GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. Fatima N, et al. Hum Pathol, 2014 Aug. PMID 24824028 A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. Joulin V., Bories D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H.EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: T-cell. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. Ho I.-C., Vorhees P., Marin N., Oakley B.K., Tsai S.-F., Orkin S.H., Leiden J.M.EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: T-cell. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: T-cell. The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Marine J., Winoto A.Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). SeattleSNPs variation discovery resourceSubmitted (DEC-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-242.