Phospho-HAND1 (S98) Polyclonal Antibody, 100µg, (ATB-P0998)

Background: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).Product datasheet: Overview Product Description Phospho-HAND1 (S98) Polyclonal Antibody, 100µg, (ATB-P0998) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human HAND1 around the phosphorylation site of S98. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors: the protein uPAR is a cytoplasmic sequestration factor for Hand-1. Asuthkar S, et al. Mol Cancer Ther, 2014 May. PMID 24623737 Two novel HAND1 mutations in Chinese patients with ventricular septal defect. Cheng Z, et al. Clin Chim Acta, 2012 Apr 11. PMID 22032825 A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Reamon-Buettner SM, et al. Hum Mol Genet, 2009 Oct 1. PMID 19586923 A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. Reamon-Buettner SM, et al. Hum Mol Genet, 2008 May 15. PMID 18276607 The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Scott IC, et al. Mol Cell Biol, 2000 Jan. PMID 10611232 Free PMC Article Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart. Knoefler M., Meinhardt G., Vasicek R., Husslein P., Egarter C.Gene 224:77-86(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Heart. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.