Phospho-IL-2Rα (S268) Polyclonal Antibody, 100µg, (ATB-P0559)

Background: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]Receptor for interleukin-2.Product datasheet: Overview Product Description Phospho-IL-2Rα (S268) Polyclonal Antibody, 100µg, (ATB-P0559) Image Species Reactivities Human Immunogen Synthesized peptide derived from human IL-2Rα around the phosphorylation site of S268. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Genetic variants in IL2RA and IL7R affect multiple sclerosis disease risk and progression. Traboulsee AL, et al. Neurogenetics, 2014 Aug. PMID 24770783 Soluble IL-2 receptor: a biomarker for assessing myositis activity. Tournadre A, et al. Dis Markers, 2014. PMID 24648607 Free PMC Article Soluble CD25 is increased in patients with sepsis-induced acute kidney injury. Cho E, et al. Nephrology (Carlton), 2014 Jun. PMID 24646167 Prognostic importance of the soluble form of IL-2 receptorα (sIL-2Rα) and its relationship with surface expression of IL-2Rα (CD25) of lymphoma cells in diffuse large B-cell lymphoma treated with CHOP-like regimen with or without rituximab: a retrospective analysis of 338 cases. Hashimoto Y, et al. J Clin Exp Hematop, 2013. PMID 24369221 Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement. Iwamuro M, et al. Clin Biochem, 2014 Feb. PMID 24362271 Molecular cloning of cDNA encoding human interleukin-2 receptor. Nikaido T., Shimizu A., Ishida N., Sabe H., Teshigawara K., Maeda M., Uchiyama T., Yodoi J., Honjo T.Nature 311:631-635(1984) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Leonard W.J., Depper J.M., Crabtree G.R., Rudikoff S., Pumphrey J., Robb R.J., Kroenke M., Svetlik P.B., Peffer N.J., Waldmann T.A., Greene W.C.Nature 311:626-631(1984) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Molecular cloning and structure of the human interleukin 2 receptor gene. Ishida N., Kanamori H., Noma T., Nikaido T., Sabe H., Suzuki N., Shimizu A., Honjo T.Nucleic Acids Res. 13:7579-7589(1985) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Structure of the human interleukin-2 receptor gene. Leonard W.J., Depper J.M., Kanehisa M., Kroenke M., Peffer N.J., Svetlik P.B., Sullivan M., Greene W.C.Science 230:633-639(1985) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. SeattleSNPs variation discovery resourceSubmitted (MAR-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-272.