Phospho-IRS-1 (S794) Polyclonal Antibody, 100µg, (ATB-P0150)

Background: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).Product datasheet: Overview Product Description Phospho-IRS-1 (S794) Polyclonal Antibody, 100µg, (ATB-P0150) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human IRS-1 around the phosphorylation site of S794. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: IRS1 G972R missense polymorphism is associated with failure to oral antidiabetes drugs in white patients with type 2 diabetes from Italy. Prudente S, et al. Diabetes, 2014 Sep. PMID 24947357 20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser616. Li X, et al. PLoS One, 2014. PMID 24763529 Free PMC Article Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk. Li P, et al. Tumour Biol, 2014 Jul. PMID 24696264 Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease. Wang W, et al. J Clin Neurosci, 2014 Jul. PMID 24589556 Increased interaction with insulin receptor substrate 1, a novel abnormality in insulin resistance and type 2 diabetes. Caruso M, et al. Diabetes, 2014 Jun. PMID 24584551 Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. Araki E., Sun X.J., Haag B.L. III, Chuang L.M., Zhang Y., Yang-Feng T.L., White M.F., Kahn C.R.Diabetes 42:1041-1054(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle. Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Nishiyama M., Wands J.R.Biochem. Biophys. Res. Commun. 183:280-285(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye. The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro. Smith L.K., Bradshaw M., Croall D.E., Garner C.W.Biochem. Biophys. Res. Commun. 196:767-772(1993) [PubMed] [Europe PMC] Cited for: TURNOVER. Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. Craparo A., O'Neill T.J., Gustafson T.A.J. Biol. Chem. 270:15639-15643(1995) [PubMed] [Europe PMC] Cited for: INTERACTION WITH IGF1R.