Phospho-KIF2C (S95) Polyclonal Antibody, 100µg, (ATB-P0566)

Background: This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.Product datasheet: Overview Product Description Phospho-KIF2C (S95) Polyclonal Antibody, 100µg, (ATB-P0566) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human KIF2C around the phosphorylation site of S95. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK. Huang R, et al. Biochem Pharmacol, 2013 Sep 1. PMID 23830822 Free PMC Article Evidence of colorectal cancer-associated mutation in MCAK: a computational report. Kumar A, et al. Cell Biochem Biophys, 2013. PMID 23564489 Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway. Gwon MR, et al. FEBS Lett, 2012 Nov 30. PMID 23098759 MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment. Domnitz SB, et al. J Cell Biol, 2012 Apr 16. PMID 22492725 Free PMC Article Control of MCAK degradation and removal from centromeres. Ganguly A, et al. Cytoskeleton (Hoboken), 2012 May. PMID 22422706 Free PMC Article Cloning and expression of human mitotic centromere-associated kinesin gene. Kim I.-G., Jun D.Y., Sohn U., Kim Y.H.Biochim. Biophys. Acta 1359:181-186(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-449, TISSUE SPECIFICITY. Tissue: T-cell. Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis. Cheng L.J., Zhou Z.M., Li J.M., Zhu H., Zhu H., Zhou Y.D., Wang L.R., Lin M., Sha J.H.Life Sci. 71:2741-2757(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-449, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Testis. Cloning of human full-length CDSs in BD Creator(TM) system donor vector. Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). MCAK/KIF2c V1. Katagiri T., Shimo A.Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-449.