Phospho-MARK1/2/3/4 (T215) Polyclonal Antibody, 100µg, (ATB-P1008)

Background: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).Product datasheet: Overview Product Description Phospho-MARK1/2/3/4 (T215) Polyclonal Antibody, 100µg, (ATB-P1008) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human MARK1/2/3/4 around the phosphorylation site of T215. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Mark/Par-1 marking the polarity of migrating neurons. Reiner O, et al. Adv Exp Med Biol, 2014. PMID 24243102 Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. Timm T, et al. BMC Neurosci, 2008 Dec 3. PMID 19090997 Free PMC Article Genome-wide association study in bipolar patients stratified by co-morbidity. Kerner B, et al. PLoS One, 2011. PMID 22205951 Free PMC Article Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. Maussion G, et al. Hum Mol Genet, 2008 Aug 15. PMID 18492799 Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2. Marx A, et al. J Biol Chem, 2006 Sep 15. PMID 16803889 LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G., Alessi D.R.EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ENZYME REGULATION, PHOSPHORYLATION AT THR-215, MUTAGENESIS OF THR-215. Cloning and isolating human MARK. Zhou H.J., Huang X.W., Zhou Y., Hu S.L., Yuan J.G., Qiang B.Q.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain1 Publication

Manually curated information for which there is published experimental evidence.