Phospho-MSK2 (T568) Polyclonal Antibody, 100µg, (ATB-P0792)

Background: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.Product datasheet: Overview Product Description Phospho-MSK2 (T568) Polyclonal Antibody, 100µg, (ATB-P0792) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human MSK2 around the phosphorylation site of T568. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1. Zhu S, et al. Hum Genet, 1998 Dec. PMID 9921902 HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2. Kang JI, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21385567 MSK activation and physiological roles. Arthur JS. Front Biosci, 2008 May 1. PMID 18508628 C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). Tomás-Zuber M, et al. J Biol Chem, 2001 Feb 23. PMID 11035004 Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction. Khan P, et al. PLoS One, 2013. PMID 23675462 Free PMC Article RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). Pierrat B., Correia J.D.S., Mary J.L., Tomas-Zuber M., Lesslauer W.J. Biol. Chem. 273:29661-29671(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, INTERACTION WITH MAPK14; MAPK1 AND MAPK3, SUBCELLULAR LOCATION. Tissue: PlacentaImported

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