Phospho-Myf-5 (S49) Polyclonal Antibody, 100µg, (ATB-P0395)

Background: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.Product datasheet: Overview Product Description Phospho-Myf-5 (S49) Polyclonal Antibody, 100µg, (ATB-P0395) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human Myf-5 around the phosphorylation site of S49. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Efficient in vitro myogenic reprogramming of human primary mesenchymal stem cells and endothelial cells by Myf5. Dimicoli-Salazar S, et al. Biol Cell, 2011 Nov. PMID 21810080 Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways. Meriane M, et al. Mol Biol Cell, 2000 Aug. PMID 10930450 Free PMC Article Altered binding of MYF-5 to FOXE1 promoter in non-syndromic and CHARGE-associated cleft palate. Venza M, et al. J Oral Pathol Med, 2009 Jan. PMID 19192046 Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106. Cupelli L, et al. Cytogenet Cell Genet, 1996. PMID 8978788 A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. Braun T, et al. EMBO J, 1989 Mar. PMID 2721498 Free PMC Article A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H.H.EMBO J. 8:701-709(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Thompson D.B.Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.