Phospho-NOS3 (T494) Polyclonal Antibody, 100µg, (ATB-P0196)

Background: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Product datasheet: Overview Product Description Phospho-NOS3 (T494) Polyclonal Antibody, 100µg, (ATB-P0196) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human NOS3 around the phosphorylation site of T494. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: The role of constitutive nitric-oxide synthase in ultraviolet B light-induced nuclear factor κB activity. Tong L, et al. J Biol Chem, 2014 Sep 19. PMID 25112869 Association of the NOS3 intron-4 VNTR polymorphism with aneurysmal subarachnoid hemorrhage. Staalsø JM, et al. J Neurosurg, 2014 Sep. PMID 24972130 Endothelial nitric oxide synthase polymorphisms and susceptibility to high-tension primary open-angle glaucoma in an Egyptian cohort. Emam WA, et al. Mol Vis, 2014. PMID 24940036 Free PMC Article Genetic variants of the endothelial NO synthase gene (eNOS) may confer increased risk of sporadic congenital heart disease. Zhou K, et al. Genet Mol Res, 2014 May 16. PMID 24938467 Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells. Arya D, et al. J Biomed Sci, 2014 Jun 4. PMID 24898615 Free PMC Article Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. Janssens S.P., Shimouchi A., Quertermous T., Bloch D.B., Bloch K.D.J. Biol. Chem. 267:14519-14522(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). ErratumJanssens S.P., Shimouchi A., Quertermous T., Bloch D.B., Bloch K.D.J. Biol. Chem. 267:22694-22694(1992) Molecular cloning and characterization of human endothelial nitric oxide synthase. Marsden P.A., Schappert K.T., Chen H.S., Flowers M., Sundell C.L., Wilcox J.N., Lamas S., Michel T.FEBS Lett. 307:287-293(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. Marsden P.A., Heng H.H.Q., Scherer S.W., Stewart R.J., Hall A.V., Shi X.-M., Tsui L.-C., Schappert K.T.J. Biol. Chem. 268:17478-17488(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Nadaud S.A., Bonnardeaux A., Lathrop M., Soubrier F.Biochem. Biophys. Res. Commun. 198:1027-1033(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.